Histone Deacetylase Activity Regulates Chemical Diversity in Aspergillus
نویسندگان
چکیده
منابع مشابه
Histone deacetylase activity regulates chemical diversity in Aspergillus.
Bioactive small molecules are critical in Aspergillus species during their development and interaction with other organisms. Genes dedicated to their production are encoded in clusters that can be located throughout the genome. We show that deletion of hdaA, encoding an Aspergillus nidulans histone deacetylase (HDAC), causes transcriptional activation of two telomere-proximal gene clusters--and...
متن کاملHistone deacetylase activity regulates chemical diversity in Aspergillus 1 2 Running Title : HDAC - mediated secondary metabolite regulation 3 4
product 53 54 55 Abstract: 56 Bioactive small molecules are critical in Aspergillus species during their development 57 and interaction with other organisms. Genes dedicated to their production are encoded in 58 clusters that can be located throughout the genome. We show that deletion of hdaA, an 59 Aspergillus nidulans histone deacetylase (HDAC), causes transcriptional activation of 60 two tel...
متن کاملA Histone Deacetylase Regulates Addiction
Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent "cellular memories." Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral...
متن کاملChemical tools for probing histone deacetylase (HDAC) activity.
Histone deacetylases (HDACs) enzymes are responsible for removing epigenetic markers on histone proteins, which results in chromatin inactivation and gene repression. An evaluation of HDAC activity is essential for not only determining the physiological function of HDACs, but also for developing HDAC-targeting drugs. This review focuses on the chemical tools used to detect HDAC activity. We hig...
متن کاملHistone Deacetylase Inhibitory Activity and Antiproliferative Activity of the Cultured Medium of Aspergillus niger strain TS1
Inhibition of histone deacetylase (HDAC) activity in cancer cells is a promising mechanism for cancer treatment. A screening program for fungi capable of producing HDAC-inhibiting molecules would lead to discovery of potential anticancer agents. The objective of this study was to isolate and characterize fungi capable of producing HDAC inhibitors from soil samples. Only one out of 48 soil funga...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2007
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.00186-07